Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

Marked QT prolongation and torsades de pointes can occur not only in the congenital long
QT syndromes (LQTSs) but also as a consequence of environmental stimuli, notably …

The mechanisms underlying many important properties of the human atrial action potential
(AP) are poorly understood. Using specific formulations of the K+, Na+, and Ca2+ currents …

Abstract Nav1. 5, the primary voltagegated Na+ (Nav) channel in heart, is a major target for
class I antiarrhythmic agents. Here we present the cryoEM structure of fulllength human …

Depolarization of human atrial myocytes activates a transient outward current that rapidly
inactivates, leaving a sustained outward current after continued depolarization. To evaluate …

Background Torsade de pointes often occurs with underlying hypokalemia and bradycardia.
A common effect of many drugs producing torsade de pointes is block of the rapidly …

Recently, great interest has been shown in understanding the functional roles of specific gap
junction proteins (connexins) in brain, lens, retina, and elsewhere. Some progress has been …

The fourth edition of Pharmacotherapy Principles & Practice is designed to provide student
learners and health care practitioners with essential knowledge of the pathophysiology and …

Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …

Several cloned K+ channel subunits are candidates to underlie macroscopic currents in the
human heart, but direct evidence bearing on their role is lacking. The Kv1. 5 K+ channel …