Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments
Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …
Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review
LA Meliante, G Piccotti, L Tanga, S Giammaria… - Journal of Clinical …, 2024 - mdpi.com
Purpose: To investigate the relationship between glaucoma, pseudoexfoliation and hearing
loss (HL). Methods: A systematic literature search following PRISMA guidelines was …
loss (HL). Methods: A systematic literature search following PRISMA guidelines was …
Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis
L Chen, HY Zhang, Y Zhang, X Li, MH Wang… - Journal of …, 2024 - Springer
Retinal neovascularisation is a major cause of blindness in patients with proliferative
diabetic retinopathy (PDR). It is mediated by the complex interaction between dysfunctional …
diabetic retinopathy (PDR). It is mediated by the complex interaction between dysfunctional …
Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma
H Zeng, JE Mayberry, D Wadkins, N Chen… - Acta neuropathologica …, 2024 - Springer
Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in
the disease results from the deterioration of retinal ganglion cells (RGC) and their axons …
the disease results from the deterioration of retinal ganglion cells (RGC) and their axons …
[HTML][HTML] The role of pericyte in ocular vascular diseases
L Shi, H Ge, F Ye, X Li, Q Jiang - Journal of Biomedical …, 2024 - pmc.ncbi.nlm.nih.gov
Pericytes are located in the stromal membrane of the capillary outer wall and contain
endothelial cells. They are pivotal in regulating blood flow, enhancing vascular stability, and …
endothelial cells. They are pivotal in regulating blood flow, enhancing vascular stability, and …
Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit
Glaucoma is a neurodegenerative disease that results in the degeneration of retinal
ganglion cells (RGCs) and subsequent loss of vision. While RGCs are the primary cell type …
ganglion cells (RGCs) and subsequent loss of vision. While RGCs are the primary cell type …
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier
E Cazalla, A Cuadrado, ÁJ García-Yagüe - Fluids and Barriers of the CNS, 2024 - Springer
Abstract Background The Blood-Brain Barrier (BBB) is a complex and dynamic interface that
regulates the exchange of molecules and cells between the blood and the central nervous …
regulates the exchange of molecules and cells between the blood and the central nervous …
Pericyte-to-endothelial cell communication via tunneling nanotubes is disrupted by a diol of docosahexaenoic acid
S Kempf, R Popp, Z Naeem, T Frömel, I Wittig, S Klatt… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms
regulating pericyte–endothelial cell communication remain unclear. This study investigated …
regulating pericyte–endothelial cell communication remain unclear. This study investigated …
New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases
CJF van Noorden, B Yetkin-Arik… - … of Histochemistry & …, 2024 - journals.sagepub.com
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a
hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk …
hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk …
Vascular resistance indices are higher in the superior than inferior optic nerve head and retina
SK Gardiner, G Cull, B Fortune - Experimental Eye Research, 2024 - Elsevier
Retinal vascular resistance is of interest in glaucoma research, as a potential link between
retinal ganglion cell loss and observed phenomena including disrupted vascular …
retinal ganglion cell loss and observed phenomena including disrupted vascular …