Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

The global incidence of obesity and its comorbidities continues to rise along with a demand
for novel therapeutic interventions. Brown adipose tissue (BAT) is attracting attention as a …

Characterizing the stem cells responsible for lung repair and regeneration is important for
the treatment of pulmonary diseases. Recently, a unique cell population located at the …

Diabetes is characterized by" glucotoxic" loss of pancreatic β cell function and insulin
content, but underlying mechanisms remain unclear. A mouse model of insulin-secretory …

Incomplete delivery to the target cells is an obstacle for successful gene therapy
approaches. Here we show unexpected effects of incomplete targeting, by demonstrating …

Skeletal muscle is essential for mobility, stability and whole body metabolism, and muscle
loss, for instance, during sarcopenia, has profound consequences. Satellite cells (muscle …

Cystic fibrosis–related (CF-related) diabetes (CFRD) is an increasingly common and
devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the …

Albumin is a promising candidate as a biomarker for potential disease diagnostics and has
been extensively used as a drug delivery carrier for decades. In these two directions, many …

Understanding the origin of pancreatic β cells has profound implications for regenerative
therapies in diabetes. For over a century, it was widely held that adult pancreatic duct cells …

Proliferating ducts, termed “oval cells,” have long been thought to be bipotential, that is,
produce both biliary ducts and hepatocytes during chronic liver injury. The precursor to oval …