Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

As an organophosphate ester (OPE), triphenyl phosphate (TPhP) has been frequently
detected in aquatic environments, and its environmental risk has been widely studied. The …

This review explores the complex interactions between polyphenols and intestinal
microorganisms, highlighting their significant impact on human health. Polyphenols …

Introduction Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked
enzymatic disorder that is particularly prevalent in Africa, Asia, and the Middle East. This …

Kidney transplantation is the therapy of choice for patients who suffer from end-stage renal
diseases. Despite improvements in surgical techniques and immunosuppressive treatments …

The Human leukocyte antigens (HLA) genes and the Killer cell immunoglobulin like
receptors (KIR) genes are critical to immune responses and are associated with many …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease
characterized by profound fatigue, post-exertional malaise (PEM), and neurocognitive …

The retinal pigment epithelium (RPE) maintains photoreceptor viability and function,
completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE …

Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases
characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles …