Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

Understanding cells as integrated systems is central to modern biology. Although
fluorescence microscopy can resolve subcellular structure in living cells, it is expensive, is …

Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …

Modern biological research particularly in the fields of developmental and cell biology has
been transformed by the rapid evolution of the light microscope. The light microscope, long a …

Mycobacterium tuberculosis modulation of macrophage cell death is a well-documented
phenomenon, but its role during bacterial replication is less characterized. In this study, we …

Developments in microscopy have been instrumental to progress in the life sciences, and
many new techniques have been introduced and led to new discoveries throughout the last …

Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically
triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in …

Serial block face scanning electron microscopy (SBF‐SEM), also referred to as serial block‐
face electron microscopy, is an advanced ultrastructural imaging technique that enables …