Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents
L Antounians, VD Catania, L Montalva, BD Liu… - Science Translational …, 2021 - science.org
Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by
decreased lung growth and maturation. The most common birth defect found in babies with …
decreased lung growth and maturation. The most common birth defect found in babies with …
Differential regulation of human surfactant protein A genes, SFTPA1 and SFTPA2, and their corresponding variants
J Floros, N Tsotakos - Frontiers in immunology, 2021 - frontiersin.org
The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-
A2, respectively, and they have been identified with significant genetic and epigenetic …
A2, respectively, and they have been identified with significant genetic and epigenetic …
Gaining insights on immune responses to the novel coronavirus, COVID-19 and therapeutic challenges
M Hajivalili, M Hosseini, M Haji-Fatahaliha - Life Sciences, 2020 - Elsevier
SARS-CoV-2 is a new member of coronaviruses that its sudden spreading put the health
care system of most countries in a tremendous shock. For controlling of the new infection …
care system of most countries in a tremendous shock. For controlling of the new infection …
[HTML][HTML] SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages
E Yau, L Yang, Y Chen, TM Umstead, AE Stanley… - Microbes and …, 2024 - Elsevier
Influenza A virus (IAV) infection causes acute and often lethal inflammation in the lung. The
role of macrophages in this adverse inflammation is partially understood. The surfactant …
role of macrophages in this adverse inflammation is partially understood. The surfactant …
Major effect of oxidative stress on the male, but not female, SP-A1 type II cell miRNome
GT Noutsios, N Thorenoor, X Zhang… - Frontiers in …, 2019 - frontiersin.org
Pulmonary surfactant protein A (SP-A) plays an important role in surfactant metabolism and
lung innate immunity. In humans there are two proteins, SP-A1 and SP-A2, encoded by …
lung innate immunity. In humans there are two proteins, SP-A1 and SP-A2, encoded by …
Interplay between C‐type lectin receptors and microRNAs in cellular homeostasis and immune response
C‐type lectin receptors (CLRs) belong to the family of pattern recognition receptors (PRRs).
They have a critical role to play in the regulation of a range of physiological functions …
They have a critical role to play in the regulation of a range of physiological functions …
Odyssey of surfactant proteins SP-A and SP-D: innate immune surveillance molecules
Surfactant protein A (SP-A) and D (SP-D) are hydrophilic collagenous C-type lectins, which
were originally discovered in the lungs associated with surfactant phospholipids. It was later …
were originally discovered in the lungs associated with surfactant phospholipids. It was later …
Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells
A Castaldi, M Horie, ME Rieger… - … of Physiology-Lung …, 2020 - journals.physiology.org
The alveolar epithelium is comprised of two cell types, alveolar epithelial type 1 (AT1) and
type 2 (AT2) cells, the latter being capable of self-renewal and transdifferentiation into AT1 …
type 2 (AT2) cells, the latter being capable of self-renewal and transdifferentiation into AT1 …
Structural and functional determinants of rodent and human surfactant protein A: a synthesis of binding and computational data
A Nalian, TM Umstead, CH Yang, P Silveyra… - Frontiers in …, 2019 - frontiersin.org
Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung
homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs) …
homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs) …
[HTML][HTML] pre-B cell colony enhancing factor negatively regulates Na+ and fluid transport in lung epithelial cells
Q Fang, M You, W Xu, W Yang, Y Gong… - American Journal of …, 2018 - ncbi.nlm.nih.gov
This study was undertaken to investigate the effect of pre-B cell colony enhancing factor
(PBEF) on Na+ and fluid transport in lung epithelial cells. Methods: Type 1 and 2 cells were …
(PBEF) on Na+ and fluid transport in lung epithelial cells. Methods: Type 1 and 2 cells were …