The role of miRNAs in liver diseases: Potential therapeutic and clinical applications

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …

MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

X Wang, Y He, B Mackowiak, B Gao - Gut, 2021 - gut.bmj.com
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

M Qi, Y Xia, Y Wu, Z Zhang, X Wang, L Lu, C Dai… - Nature …, 2022 - nature.com
The formation of pre-metastatic niche is a key step in the metastatic burden. The pluripotent
factor Lin28B is frequently expressed in breast tumors and is particularly upregulated in the …

MicroRNA let-7 and viral infections: focus on mechanisms of action

A Letafati, S Najafi, M Mottahedi, M Karimzadeh… - Cellular & molecular …, 2022 - Springer
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …

Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view

S Thietart, PE Rautou - Journal of hepatology, 2020 - Elsevier
Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and
microRNAs. They can originate from both healthy and stressed cells, and provide a …

Molecular and functional roles of microRNAs in the progression of hepatocellular carcinoma—a review

K Oura, A Morishita, T Masaki - International journal of molecular sciences, 2020 - mdpi.com
Liver cancer is the fourth leading cause of cancer deaths globally, of which hepatocellular
carcinoma (HCC) is the major subtype. Viral hepatitis B and C infections, alcohol abuse, and …

Mechanisms underlying hepatitis C virus-associated hepatic fibrosis

M Khatun, RB Ray - Cells, 2019 - mdpi.com
Hepatitis C virus (HCV) infection often causes liver diseases, including fibrosis, cirrhosis and
hepatocellular carcinoma (HCC). Liver fibrosis is the outcome of the wound healing …

MicroRNAs in the pathogenesis of hepatocellular carcinoma: a review

A Morishita, K Oura, T Tadokoro, K Fujita, J Tani… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the most frequently occurring
cancers, and the prognosis for late-stage HCC remains poor. A better understanding of the …

MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47phox–oxidative stress pathway in neutrophils

M Li, Y He, Z Zhou, T Ramirez, Y Gao, Y Gao, RA Ross… - Gut, 2017 - gut.bmj.com
Objectives Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver
injury in mice. This study investigates how recent excessive drinking affects peripheral …

miRNAs as potential biomarkers for viral hepatitis B and C

D Loureiro, I Tout, S Narguet, SM Benazzouz… - Viruses, 2020 - mdpi.com
Around 257 million people are living with hepatitis B virus (HBV) chronic infection and 71
million with hepatitis C virus (HCV) chronic infection. Both HBV and HCV infections can lead …