Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours;
however, state-of-the-art measurements have revealed that many of the molecular …

Determining whether and how a gene is transcribed are two of the central processes of life.
The conceptual basis for understanding such gene regulation arose from pioneering …

Living things benefit from exquisite molecular sensitivity in many of their key processes,
including DNA replication, transcription and translation, chemical sensing, and …

Predicting how interactions between transcription factors and regulatory DNA sequence
dictate rates of transcription and, ultimately, drive developmental outcomes remains an open …

The limits on a system's response to external perturbations inform our understanding of how
physical properties can be shaped by microscopic characteristics. Here, we derive …

Integration of binding information by macromolecular entities is fundamental to cellular
functionality. Recent work has shown that such integration cannot be explained by pairwise …

During development, gene regulatory networks allocate cell fates by partitioning tissues into
spatially organised domains of gene expression. How the sharp boundaries that delineate …

How enhancers interpret morphogen gradients to generate gene expression patterns is a
central question in developmental biology. Recent studies have proposed that enhancers …

Spatially distributed signaling molecules, known as morphogens, provide spatial information
during development. A host of different morphogens have now been identified, from …

Cell fate decisions in the fly embryo are rapid: hunchback genes decide in minutes whether
nuclei follow the anterior/posterior developmental blueprint by reading out positional …