Targeting myeloperoxidase (MPO) mediated oxidative stress and inflammation for reducing brain ischemia injury: Potential application of natural compounds
Oxidative stress and inflammation are two critical pathological processes of cerebral
ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and …
ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and …
Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …
A highly selective and sensitive chemiluminescent probe for real‐time monitoring of hydrogen peroxide in cells and animals
Selective and sensitive molecular probes for hydrogen peroxide (H2O2), which plays
diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the …
diverse roles in oxidative stress and redox signaling, are urgently needed to investigate the …
Roles of nitric oxide in brain ischemia and reperfusion
Y Wang, F Hong, S Yang - International journal of molecular sciences, 2022 - mdpi.com
Brain ischemia and reperfusion (I/R) is one of the most severe clinical manifestations of
ischemic stroke, placing a significant burden on both individuals and society. The only FDA …
ischemic stroke, placing a significant burden on both individuals and society. The only FDA …
Healthy serum-derived exosomes improve neurological outcomes and protect blood–brain barrier by inhibiting endothelial cell apoptosis and reversing autophagy …
LY Huang, JX Song, H Cai, PP Wang, QL Yin… - Frontiers in Cellular …, 2022 - frontiersin.org
Blood–brain barrier (BBB) dysfunction causing edema and hemorrhagic transformation is
one of the pathophysiological characteristics of stroke. Protection of BBB integrity has shown …
one of the pathophysiological characteristics of stroke. Protection of BBB integrity has shown …
Momordica charantia Exosome-Like Nanoparticles Exert Neuroprotective Effects Against Ischemic Brain Injury via Inhibiting Matrix Metalloproteinase 9 and …
H Cai, LY Huang, R Hong, JX Song, XJ Guo… - Frontiers in …, 2022 - frontiersin.org
Plant exosome-like nanoparticles (ELNs) have shown great potential in treating tumor and
inflammatory diseases, but the neuroprotective effect of plant ELNs remains unknown. In the …
inflammatory diseases, but the neuroprotective effect of plant ELNs remains unknown. In the …
Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy
T Duan, L Li, Y Yu, T Li, R Han, X Sun, Y Cui… - Pharmacological …, 2022 - Elsevier
Intracerebral hemorrhage (ICH) refers to hemorrhage caused by non-traumatic vascular
rupture in the brain parenchyma, which is characterized by acute onset, severe illness, and …
rupture in the brain parenchyma, which is characterized by acute onset, severe illness, and …
Inhibition of peroxynitrite-induced mitophagy activation attenuates cerebral ischemia-reperfusion injury
J Feng, X Chen, B Guan, C Li, J Qiu, J Shen - Molecular neurobiology, 2018 - Springer
Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its
roles remain controversial. Peroxynitrite (ONOO−), as a representative of reactive nitrogen …
roles remain controversial. Peroxynitrite (ONOO−), as a representative of reactive nitrogen …
Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis through targeting peroxynitrite …
H Chen, B Guan, B Wang, H Pu, X Bai, X Chen… - Translational Stroke …, 2020 - Springer
Peroxynitrite (ONOO−) and high mobility group box 1 protein (HMGB1) are important
cytotoxic factors contributing to cerebral ischemia-reperfusion injury. However, the roles of …
cytotoxic factors contributing to cerebral ischemia-reperfusion injury. However, the roles of …
Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation
J Feng, X Chen, S Lu, W Li, D Yang, W Su… - Molecular …, 2018 - Springer
Excessive autophagy/mitophagy plays important roles during cerebral ischemia-reperfusion
(I/R) injury. Peroxynitrite (ONOO−), a representative reactive nitrogen species, mediates …
(I/R) injury. Peroxynitrite (ONOO−), a representative reactive nitrogen species, mediates …