American trypanosomiasis (Chagas disease)

LE Echeverria, CA Morillo - Infectious Disease Clinics, 2019 - id.theclinics.com
Chagas disease (CD), also known as American trypanosomiasis, is a multisystemic disorder
that can affect the cardiovascular, digestive, and central nervous systems. 1 CD is caused by …

Chagas disease as example of a reemerging parasite

J Guarner - Seminars in diagnostic pathology, 2019 - Elsevier
Trypanosoma cruzi, the protozoan that causes Chagas disease, is primarily transmitted by
three main Triatomine vectors in endemic areas. However, the infection has become a …

Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues

D Silva-dos-Santos… - PLoS neglected …, 2017 - journals.plos.org
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most
important route of infection in Brazilian Amazon and Venezuela. Other South American …

Animal models of Chagas disease and their translational value to drug development

E Chatelain, I Scandale - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction American trypanosomiasis, better known as Chagas disease, is a global public
health issue. Current treatments targeting the causative parasite, Trypanosoma cruzi, are …

[HTML][HTML] American trypanosomiasis and Chagas disease: Sexual transmission

C Gomes, AB Almeida, AC Rosa, PF Araujo… - International Journal of …, 2019 - Elsevier
Objective To contribute to the discussion on the research findings indicating the sexual
transmission of American trypanosomiasis and Chagas disease in humans. Methods A …

Correlation of parasite burden, kDNA integration, autoreactive antibodies, and cytokine pattern in the pathophysiology of Chagas disease

M Wesley, A Moraes, AC Rosa… - Frontiers in …, 2019 - frontiersin.org
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi (T. cruzi), is the main
parasitic disease in the Western Hemisphere. Unfortunately, its physiopathology is not …

Comparative high-throughput analysis of the Trypanosoma cruzi response to organometallic compounds

MF Mosquillo, P Smircich, M Ciganda, A Lima… - Metallomics, 2020 - academic.oup.com
There is an urgent need to develop new drugs against Chagas' disease. In addition, the
mechanisms of action of existing drugs have not been completely worked out at the …

Noninvasive biological samples to detect and diagnose infections due to trypanosomatidae parasites: A systematic review and meta-analysis

D Sereno, M Akhoundi, K Sayehmri, A Mirzaei… - International Journal of …, 2020 - mdpi.com
Unicellular eukaryotes of the Trypanosomatidae family include human and animal
pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the …

The use of qPCR in human Chagas disease: a systematic review

L Hagström, ALP Marques, N Nitz… - Expert Review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: The diagnosis in Chagas disease is a challenge because most
infections with Trypanosoma cruzi are asymptomatic and currently serological tests have …

Can sexual transmission support the enzootic cycle of Trypanosoma cruzi?

A Rios, M Ribeiro, A Sousa, F Pimentel… - Memórias do Instituto …, 2018 - SciELO Brasil
BACKGROUND Trypanosoma cruzi circulates in sylvatic habitats, mainly through blood-
feeding triatomines, although other routes also contribute to its dispersion. Sexual …