ABSTRACT A major challenge in the biology of aging is to understand how specific age-
onset pathologies relate to the overall health of the organism. The integrity of the intestinal …

Inflammaging, characterized by persistent chronic inflammation in older adults, has emerged
as a critical factor linked to age-related diseases such as cardiovascular diseases (CVDs) …

Age-related changes to histone levels are seen in many species. However, it is unclear
whether changes to histone expression could be exploited to ameliorate the effects of …

Pharmacological attenuation of mTOR presents a promising route for delay of age-related
disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin …

Host-microbe interactions influence intestinal stem cell (ISC) activity to modulate epithelial
turnover and composition. Here, we investigated the functional impacts of viral infection on …

Insect ommochrome biosynthesis pathways metabolize tryptophan to generate eye-color
pigments and wild-type alleles of pathway genes are useful phenotypic markers in …

Previous work in our laboratory has shown that mutations in prickle (pk) cause myoclonic-
like seizures and ataxia in Drosophila, similar to what is observed in humans carrying …

Pickering emulsions assembled from biopolymer nanoelements are promising as forms of
oral delivery systems. In this study, rod-like partially acetylated cellulose nanocrystals (CNC …

Parameters correlated with age and mortality in Drosophila melanogaster include
decreased negative geotaxis and centrophobism behaviors, decreased climbing and …

The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the
intricate exchange between internal and external environments. Anchored by evolutionarily …