Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus)

M Liu, PE Hansen, G Wang, L Qiu, J Dong, H Yin… - Molecules, 2015 - mdpi.com
The female inflorescences of hops (Humulus lupulus L.), a well-known bittering agent used
in the brewing industry, have long been used in traditional medicines. Xanthohumol (XN) is …

An update on antitumor activity of naturally occurring chalcones

EH Zhang, RF Wang, SZ Guo… - … Based Complementary and …, 2013 - Wiley Online Library
Chalcones, which have characteristic 1, 3‐diaryl‐2‐propen‐1‐one skeleton, are mainly
produced in roots, rhizomes, heartwood, leaves, and seeds of genera Angelica, Sophora …

Cancer chemoprevention revisited: cytochrome P450 family 1B1 as a target in the tumor and the microenvironment

G D'Uva, D Baci, A Albini, DM Noonan - Cancer treatment reviews, 2018 - Elsevier
Cancer chemoprevention is the use of synthetic, natural or biological agents to prevent or
delay the development or progression of malignancies. Intriguingly, many phytochemicals …

Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells

R Negrao, R Costa, D Duarte… - Journal of cellular …, 2010 - Wiley Online Library
Emerging evidence indicates that chronic inflammation and oxidative stress cluster together
with angiogenic imbalance in a wide range of pathologies. In general, natural polyphenols …

[HTML][HTML] Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation

C Gallo, K Dallaglio, B Bassani, T Rossi, A Rossello… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Angiogenesis, a process characterized by the formation of new blood vessels from pre-
existing ones, is a crucial step in tumor growth and dissemination. Recently, increased …

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo

R Liu, EH Heiss, D Schachner, B Jiang… - Journal of natural …, 2017 - ACS Publications
Xanthohumol (1) is a principal prenylated chalcone found in hops. The aim of this study was
to examine its influence on platelet-derived growth factor (PDGF)-BB-triggered vascular …

Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways

B Rizeq, I Gupta, H Kheraldine, D Elkhalifa… - International Journal of …, 2021 - mdpi.com
Natural chalcones possess antitumor properties and play a role as inducers of apoptosis,
antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone …

Nutrigenetics, nutrigenomics and phenotypic outcomes of dietary low-dose alcohol consumption in the suppression and induction of cancer development: evidence …

F Caradonna, I Cruciata, C Luparello - Critical reviews in food …, 2022 - Taylor & Francis
It is known that the intake of alcoholic beverages may impair genetic and epigenetic
regulatory events with consequent crucial effects on cell phenotypes and that its association …

Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B …

R Negrão, D Duarte, R Costa, R Soares - Biofactors, 2013 - Wiley Online Library
Angiogenesis and inflammation are becoming distinguished players in the pathogenesis of
many heterogeneous diseases, such as diabetes, cardiovascular disease, and cancer …

Poly (ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial re-population, bio-mechanical and anti-thrombogenic properties of decellularized …

E López-Ruiz, S Venkateswaran, M Perán… - Scientific Reports, 2017 - nature.com
Decellularized vascular scaffolds are promising materials for vessel replacements. However,
despite the natural origin of decellularized vessels, issues such as biomechanical …