Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and
usually has its onset during youth. Its chronic course is associated with high rates of …

Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …

Purpose of review. In this review, we provide an update of recent studies on the age of onset
(AOO) of the major mental disorders, with a special focus on the availability and use of …

Objective: The authors sought to identify diagnostic risk factors of manic, mixed, or
hypomanic episodes in the offspring of parents with bipolar disorder (“high-risk offspring”) …

Although the onset of most mental disorders usually occurs during the first three decades of
life, effective treatment is typically not initiated until a number of years later. Although there is …

Depression is a highly heterogeneous syndrome that bears only modest correlations with its
biological substrates, motivating a renewed interest in rethinking our approach to …

Objective: High rates of misdiagnosis, delayed diagnosis, and lack of recognition and
treatment of comorbid conditions often lead patients with bipolar illness to have a chronic …

Objectives To clarify the clinical features preceding the onset of bipolar disorder (BD) has
become a public health priority for the prevention of high morbidity and mortality. BD …

Rosa AR, González‐Ortega I, González‐Pinto A, Echeburúa E, Comes M, Martínez‐Àran A,
Ugarte A, Fernández M, Vieta E. One‐year psychosocial functioning in patients in the early …