Functional aging in male C57BL/6J mice across the life-span: a systematic behavioral analysis of motor, emotional, and memory function to define an aging phenotype
S Yanai, S Endo - Frontiers in aging neuroscience, 2021 - frontiersin.org
Aging is characterized generally by progressive and overall physiological decline of
functions and is observed in all animals. A long line of evidence has established the …
functions and is observed in all animals. A long line of evidence has established the …
The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice
C Ingvorsen, NA Karp, CJ Lelliott - Nutrition & diabetes, 2017 - nature.com
Background: Metabolic disorders are commonly investigated using knockout and transgenic
mouse models on the C57BL/6N genetic background due to its genetic susceptibility to the …
mouse models on the C57BL/6N genetic background due to its genetic susceptibility to the …
The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level
The phenotype of an organism results from its genotype and the influence of the
environment throughout development. Even when using animals of the same genotype …
environment throughout development. Even when using animals of the same genotype …
Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice
Key points Traditionally the female sex, compared with the male sex, has been perceived as
having greater variability in many physiological traits, including within the immune system …
having greater variability in many physiological traits, including within the immune system …
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
H Kollmus, H Fuchs, C Lengger, H Haselimashhadi… - Mammalian …, 2020 - Springer
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight
founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ …
founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ …
Frameshift mutation of Timm8a1 gene in mouse leads to an abnormal mitochondrial structure in the brain, correlating with hearing and memory impairment
P Song, Y Guan, X Chen, C Wu, A Qiao… - Journal of Medical …, 2021 - jmg.bmj.com
Background Deafness-dystonia-optic neuronopathy (DDON) syndrome is a progressive X-
linked recessive disorder characterised by deafness, dystonia, ataxia and reduced visual …
linked recessive disorder characterised by deafness, dystonia, ataxia and reduced visual …
Strategies for behaviorally phenotyping the transgenic mouse
KE McCarson - Transgenic Mouse: Methods and Protocols, 2020 - Springer
The techniques and protocols to modify the mouse genome described in this volume allow
researchers to produce genetic models of a remarkable number and breadth of human …
researchers to produce genetic models of a remarkable number and breadth of human …
Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks
R Casero, H Westerberg, NR Horner, M Yon… - bioRxiv, 2021 - biorxiv.org
White adipose tissue (WAT) plays a central role in metabolism, with multiple diseases and
genetic mutations causing its remodeling. Quantitative analysis of white adipocyte size is of …
genetic mutations causing its remodeling. Quantitative analysis of white adipocyte size is of …
Thematic issue of the Second combined Bio-ontologies and Phenotypes Workshop
This special issue covers selected papers from the 18th Bio-Ontologies Special Interest
Group meeting and Phenotype Day, which took place at the Intelligent Systems for …
Group meeting and Phenotype Day, which took place at the Intelligent Systems for …
個別化医療・個別化予防を推進するオントロジー
高井貴子 - 日本化学会情報化学部会誌, 2017 - jstage.jst.go.jp
オントロジーは, 人間が共有する背景知識を, 計算機を利用した演算処理を可能としたものである.
今日ゲノム科学領域において頻用されている Gene ontology [1] は, まさに生物学者が共有する …
今日ゲノム科学領域において頻用されている Gene ontology [1] は, まさに生物学者が共有する …