Integration of the reverse-transcribed viral DNA into the host genome is an essential step in
the life cycle of retroviruses. Retrovirus integrase catalyses insertions of both ends of the …

Fumonisins are polyketide-derived mycotoxins produced by Fusarium verticillioides, a
fungal pathogen of corn plants. Although a gene cluster for the biosynthesis of fumonisins …

Background Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by
the human immunodeficiency virus (HIV). Successful development of ART can be …

Integration of the retrovirus linear DNA genome into the host chromosome is an essential
step in the viral replication cycle, and is catalyzed by the viral integrase (IN). Evidence …

A functional study of mutants of the human immunodeficiency virus type 1 (HIV-1) integrase
(IN) was conducted with the support of a recently proposed HIV-1 intasome model. Firstly …

We determined conditions to produce milligram quantities of the soluble Rous sarcoma virus
(RSV) synaptic complex that is kinetically trapped by HIV strand transfer inhibitors (STIs) …

HIV integrase (HIV-IN), one of three HIV enzymes, is a target for the treatment of AIDS, but
the full biological assembly has been difficult to characterize, hampering inhibitor design …

Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in
the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus …

Collaborations between the Wlodawer and Skalka laboratories have covered a period of
almost 30 years. During that time our groups have co-authored 18 publications, including …

The human immunodeficiency virus (HIV) affects millions of people worldwide who rely on
antiretroviral therapy to prevent the acquired immunodeficiency syndrome and halt further …