Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Extracellular vesicles (EVs) are nanosized vesicles released by normal and diseased cells
as a novel form of intercellular communication and can serve as an effective therapeutic …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Pannexin 1 (PANX1) channels mediate release of ATP, a" find-me" signal that recruits
macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase …

Astrocytes have a role in maintaining normal neuronal functions, some of which depend on
connexins, protein subunits of gap junction channels and hemichannels. Under …

Pannexins, a class of membrane channels, bear significant sequence homology with the
invertebrate gap junction proteins, innexins, and more distant similarities in their membrane …

The increasing use of nanoparticles in medicine has raised concerns over their ability to
gain access to privileged sites in the body. Here, we show that cobalt–chromium …

Pannexins are mammalian orthologs of the invertebrate gap junction proteins innexins and
thus have been proposed to play a role in gap junctional intercellular communication …

Astrocytes can release the excitatory transmitter glutamate which is capable of modulating
activity in nearby neurons. This astrocytic glutamate release can occur through six known …