Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …

Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4
(GPX4). At present, mechanisms that could predict sensitivity and/or resistance and that may …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

The primary physiological function of mitochondria is to generate adenosine triphosphate
through oxidative phosphorylation via the electron transport chain. Overproduction of …

Excess production of reactive oxygen species in the brain has been implicated as a common
underlying risk factor for the pathogenesis of a number of neurodegenerative disorders …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Stroke is the third leading cause of death in industrialized countries and one of the largest
causes of permanent disability worldwide. Therapeutic options to fight stroke are still limited …

Protein aggregation critically affects cell viability in neurodegenerative diseases, but
whether this also occurs in ischemic brain injury remains elusive. Prior studies report the …