There is no effective treatment for late stage and metastatic cancers of colorectal, prostate,
pancreatic, breast, glioblastoma and melanoma cancers. Novel treatment modalities are …

Cancer gene therapy has been one of the most exciting areas of therapeutic research in the
past decade. In this review, we discuss strategies to restrict transcription of transgenes to …

This review focuses on the prodrugs used in suicide gene therapy. These prodrugs need to
satisfy a number of criteria. They must be efficient and selective substrates for the activating …

A global gene expression analysis using oligonucleotide microarrays was performed on
many human small cell lung cancer (SCLC) cell lines in cell culture and/or as xenografts …

Replication-competent retrovirus (RCR) vectors are intrinsically incapable of infecting
quiescent cells and have been shown to achieve highly efficient and tumor-restricted …

Cell-based gene therapy holds considerable promise for the treatment of human
malignancy. Genetically engineered cells if delivered to sites of disease could alleviate …

US10035983B2 - Gene therapy vectors and cytosine deaminases - Google Patents
US10035983B2 - Gene therapy vectors and cytosine deaminases - Google Patents Gene therapy …

Human carcinoembryonic antigen (CEA) is overexpressed in most colorectal cancers and
has been widely used as a clinical marker for the management of colon cancer patients. The …

Purpose: This study aimed to develop an efficient and safe strategy to introduce suicide
genes into colon cancer cells. Experimental Design: In this study, we fused an enhanced …

Current treatment of solid tumors with standard of care chemotherapies, radiation therapy
and/or immunotherapies are often limited by severe adverse toxic effects, resulting in a …