Eukaryotic cell size control and its relation to biosynthesis and senescence
The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
The bidirectional relationship between metabolism and cell cycle control
FF Diehl, KM Sapp, MG Vander Heiden - Trends in Cell Biology, 2024 - cell.com
The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells
Multicellular organisms use mitogens to regulate cell proliferation, but how fluctuating
mitogenic signals are converted into proliferation-quiescence decisions is poorly …
mitogenic signals are converted into proliferation-quiescence decisions is poorly …
Nutrient availability as an arbiter of cell size
DR Kellogg, PA Levin - Trends in cell biology, 2022 - cell.com
Pioneering work carried out over 60 years ago discovered that bacterial cell size is
proportional to the growth rate set by nutrient availability. This relationship is traditionally …
proportional to the growth rate set by nutrient availability. This relationship is traditionally …
[HTML][HTML] Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle
Many cell biological and biochemical mechanisms controlling the fundamental process of
eukaryotic cell division have been identified; however, the temporal dynamics of biosynthetic …
eukaryotic cell division have been identified; however, the temporal dynamics of biosynthetic …
The metabolic growth limitations of petite cells lacking the mitochondrial genome
Eukaryotic cells can survive the loss of their mitochondrial genome, but consequently suffer
from severe growth defects.'Petite yeasts', characterized by mitochondrial genome loss, are …
from severe growth defects.'Petite yeasts', characterized by mitochondrial genome loss, are …
[HTML][HTML] Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
Amino acid homeostasis is critical for many cellular processes. It is well established that
amino acids are compartmentalized using pH gradients generated between organelles and …
amino acids are compartmentalized using pH gradients generated between organelles and …
[HTML][HTML] Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
Biosynthesis scales with cell size such that protein concentrations generally remain constant
as cells grow. As an exception, synthesis of the cell-cycle inhibitor Whi5" sub-scales" with …
as cells grow. As an exception, synthesis of the cell-cycle inhibitor Whi5" sub-scales" with …
Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle-and cell size-dependent growth
Cell size is believed to influence cell growth and metabolism. Consistently, several studies
have revealed that large cells have lower mass accumulation rates per unit mass (ie, growth …
have revealed that large cells have lower mass accumulation rates per unit mass (ie, growth …
[HTML][HTML] What programs the size of animal cells?
The human body is programmed with definite quantities, magnitudes, and proportions. At the
microscopic level, such definite sizes manifest in individual cells-different cell types are …
microscopic level, such definite sizes manifest in individual cells-different cell types are …