The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Multicellular organisms use mitogens to regulate cell proliferation, but how fluctuating
mitogenic signals are converted into proliferation-quiescence decisions is poorly …

Pioneering work carried out over 60 years ago discovered that bacterial cell size is
proportional to the growth rate set by nutrient availability. This relationship is traditionally …

Many cell biological and biochemical mechanisms controlling the fundamental process of
eukaryotic cell division have been identified; however, the temporal dynamics of biosynthetic …

Eukaryotic cells can survive the loss of their mitochondrial genome, but consequently suffer
from severe growth defects.'Petite yeasts', characterized by mitochondrial genome loss, are …

Amino acid homeostasis is critical for many cellular processes. It is well established that
amino acids are compartmentalized using pH gradients generated between organelles and …

Biosynthesis scales with cell size such that protein concentrations generally remain constant
as cells grow. As an exception, synthesis of the cell-cycle inhibitor Whi5" sub-scales" with …

Cell size is believed to influence cell growth and metabolism. Consistently, several studies
have revealed that large cells have lower mass accumulation rates per unit mass (ie, growth …

The human body is programmed with definite quantities, magnitudes, and proportions. At the
microscopic level, such definite sizes manifest in individual cells-different cell types are …