Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …

Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …

Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …

Cytokines are proteins secreted in the central nervous system by neurons, microglia,
astrocytes and infiltrating peripheral immune cells under physiological and pathological …

There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …

The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …

Innate immunity within the central nervous system (CNS) is primarily provided by resident
microglia. Microglia are pivotal in immune surveillance and also facilitate the co‐ordinated …

Glia of the central nervous system (CNS) help to maintain homeostasis in the brain and
support efficient neuronal function. Microglia are innate immune cells of the brain that …

Despite tremendous investments in understanding the complex molecular mechanisms
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …