Neurodegeneration leads to the loss of structural and functioning components of neurons
over time. Various studies have related neurodegeneration to a number of degenerative …

In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …

Tau aggregates contribute to neurodegenerative diseases, including frontotemporal
dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro …

Tau aggregation is a defining histopathological feature of Alzheimer's disease and other
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …

Abstract Disruption of calcium (Ca 2+) homeostasis is emerging as a prevalent feature of
aging and aging-associated neurodegenerative diseases, including Alzheimer's disease …

Limited comparative data exist on the molecular spectrum of amyloid-beta (Aβ) and tau
deposition in individuals with Down syndrome (DS) and sporadic Alzheimer's disease (sAD) …

Tau deposits in astrocytes are frequently found in Alzheimer's disease (AD) and other
tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be …

Introduction Alzheimer's disease (AD) biomarkers are increasingly more reliable in
predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early …

Previous research demonstrated that genetic heterogeneity is a critical factor in modeling
amyloid accumulation and other Alzheimer's disease phenotypes. However, it is unknown …

Alzheimer's disease (AD) and other tauopathies are histopathologically characterized by tau
aggregation, along with a chronic inflammatory response driven by microglia. Over the past …