The fragility of tourniquet use in total knee arthroplasty: A systematic review of randomized controlled trials
JK Cordero, KW Lawrence, AN Brown, X Li… - The Journal of …, 2023 - Elsevier
Background Physicians utilize P-values to interpret clinical trial data and guide patient-care
decisions. Fragility analysis assesses the stability of statistical findings in relation to outcome …
decisions. Fragility analysis assesses the stability of statistical findings in relation to outcome …
[HTML][HTML] Assessing the robustness of COVID-19 vaccine efficacy trials: systematic review and meta-analysis, January 2023
Background Vaccines play a crucial role in the response to COVID-19 and their efficacy is
thus of great importance. Aim To assess the robustness of COVID-19 vaccine efficacy (VE) …
thus of great importance. Aim To assess the robustness of COVID-19 vaccine efficacy (VE) …
Fragility indices for only sufficiently likely modifications
BR Baer, M Gaudino, M Charlson… - Proceedings of the …, 2021 - National Acad Sciences
The fragility index is a clinically meaningful metric based on modifying patient outcomes that
is increasingly used to interpret the robustness of clinical trial results. The fragility index …
is increasingly used to interpret the robustness of clinical trial results. The fragility index …
Reverse fragility index comparing rates of rerupture after open Achilles tendon repair versus early functional rehabilitation: a systematic review of randomized …
JT Bragg, VCB Ruelos, JA McIntyre… - … American Journal of …, 2024 - journals.sagepub.com
Background: Despite similar published rates of rerupture among patients treated with early
functional rehabilitation and open repair for acute Achilles tendon rupture, uncertainty still …
functional rehabilitation and open repair for acute Achilles tendon rupture, uncertainty still …
The reverse fragility index: interpreting the current literature on long-term survivorship of computer-Navigated versus conventional TKA: A systematic review and cross …
JL Shi, ES Mojica, MA Moverman, NR Pagani… - JBJS, 2023 - journals.lww.com
Background: Despite the most recent American Academy of Orthopaedic Surgeons clinical
practice guideline making a “strong” recommendation against the use of intraoperative …
practice guideline making a “strong” recommendation against the use of intraoperative …
The fragility index can be used for sample size calculations in clinical trials
BR Baer, M Gaudino, SE Fremes, M Charlson… - Journal of clinical …, 2021 - Elsevier
Objective: The fragility index is a clinically interpretable metric increasingly used to interpret
the robustness of clinical trials results that is generally not incorporated in sample size …
the robustness of clinical trials results that is generally not incorporated in sample size …
The majority of sports medicine and arthroscopy-related randomized controlled trials reporting nonsignificant results are statistically fragile
SY Sudah, MA Moverman, R Masood, ES Mojica… - … : The Journal of …, 2023 - Elsevier
Purpose To evaluate the robustness of sports medicine and arthroscopy related randomized
controlled trials (RCTs) reporting nonsignificant results by calculating the reverse fragility …
controlled trials (RCTs) reporting nonsignificant results by calculating the reverse fragility …
The fragility index for assessing the robustness of the statistically significant results of experimental clinical studies
AK Ho - Journal of General Internal Medicine, 2022 - Springer
I na randomized controlled trial (RCT) comparing treatments A and B, a null hypothesis (H0)
of no difference in a primary outcome of interest is defined. Whether any observed difference …
of no difference in a primary outcome of interest is defined. Whether any observed difference …
To guide future practice, perinatal trials should be much larger, simpler and less fragile with close to 100% ascertainment of mortality and other key outcomes
Abstract The Australian Placental Transfusion Study (APTS) randomised 1,634 fetuses to
delayed (≥ 60 s) versus immediate (≤ 10 s) clamping of the umbilical cord. Systematic …
delayed (≥ 60 s) versus immediate (≤ 10 s) clamping of the umbilical cord. Systematic …
The reverse fragility index: RCTs reporting non-significant differences in failure rates between hamstring and bone–patellar tendon–bone autografts have fragile …
VCB Ruelos, R Masood, RN Puzzitiello… - Knee Surgery, Sports …, 2023 - Springer
Purpose The reverse fragility index (RFI) is a novel metric to appraise the results of studies
reporting statistically non-significant results. The purpose of this study was to determine the …
reporting statistically non-significant results. The purpose of this study was to determine the …