Tumor cells express a high quantity of exosomes packaged with unique cargos under
hypoxia, an important characteristic feature in solid tumors. These hypoxic tumor-derived …

Cancer is an unprecedented proliferation of cells leading to abnormalities in differentiation
and maturation. Treatment of primary and metastatic cancer is challenging. In addition to …

The efficacy of cancer therapies is limited to a great extent by immunosuppressive
mechanisms within the tumor microenvironment (TME). Numerous immune escape …

Background The expression of Fucosidase, alpha-L-2 (FUCA2) varies across tumors.
However, its role in various tumor types and relationship with the tumor immune …

Simple Summary Mucosal associated invariant T (MAIT) cells are a population of innate T
cells which play an important role in host protection against bacterial, fungi and viruses …

The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in
recent years have fuelled the ongoing development of this class of drugs. These novel …

Background: Adaptor-related protein complex 3, sigma one subunit (AP3S1) is one of the
encoding subunits of the adaptor complex AP-3. However, its role in various tumor types and …

Background Recent studies have identified ribonucleotide reductase subunit M2 (RRM2) as
a putative promoter of tumors. However, no systematic analysis of its carcinogenicity has …

An improved understanding of the molecular mechanism of colorectal adenocarcinoma is
necessary to predict the prognosis and develop new target gene therapy strategies. This …

Objective Shc SH2 domain-binding protein (SHCBP1) is involved in regulating tumour
progression in a variety of tumour types. The aim of this study was to analyze the prognostic …