Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most
frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the …

Older people represent the fastest growing group with epilepsy diagnosis. For example,
cerebrovascular disease may underlie roughly 30–50% of epilepsy in older adults and …

Metabolic modulation of neuronal excitability is becoming increasingly important as an
antiepileptic therapy. It was reported that the glycolytic inhibitor 2-deoxy-d-glucose (2-DG) …

Homer1a regulates expression of group I metabotropic glutamate receptors type I (mGluR1
and mGluR5) and is involved in neuronal plasticity. It has been reported that Homer1a …

Introduction and Objectives Cognitive impairment is a significant comorbidity of temporal
lobe epilepsy that is associated with extensive hippocampal cell loss. Deep brain stimulation …

Prematurely-born infants are exposed to multiple invasive procedures while in the intensive
care unit. Newborn rats and humans have similar behavioral responses to noxious …

Adenosine is an endogenous anticonvulsant that activates pre-and postsynaptic adenosine
A 1 receptors. A 1 receptor agonists increase the latency for the development of seizures …

It is known that the incidence of epilepsy increases with age, but only a few studies have
investigated the consequences and mechanisms of seizure and epilepsy in aged animals …

Objective Genetic Absence Epilepsy Rat from Strasbourg (GAERS), a rodent model
genetically predisposed to absence epilepsy, serves as an experimental tool to elucidate the …

To understand the potential role of enhanced hippocampal neurogenesis after pilocarpine-
induced status epilepticus (SE) in the development of epilepsy, we quantitatively analyzed …