The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

The retinoblastoma gene was identified over a decade ago as the first tumor suppressor.
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …

The unfolded protein response (UPR), caused by stress, matches the folding capacity of
endoplasmic reticulum (ER) to the load of client proteins in the organelle,. In yeast …

We describe a novel 25 kDa protein, geminin, which inhibits DNA replication and is
degraded during the mitotic phase of the cell cycle. Geminin has a destruction box sequence …

Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through
the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity—by …

Proteolysis mediated by the anaphase-promoting complex (APC) triggers chromosome
segregation and exit from mitosis, yet its regulation is poorly understood. The conserved …

Key events in mitosis such as sister chromatid separation and subsequent inactivation of
cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events …

Many tumorigenic processes affect cell-cycle progression by their effects on the levels of the
cyclin-dependent kinase inhibitor p27 Kip1 [1, 2]. The phosphorylation-and ubiquitination …

Abstract p27 is a cell cycle inhibitor whose cellular abundance increases in response to
many antimitogenic stimuli. In this review, we summarize the current knowledge on p27 …

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family.
p27 expression is regulated by cell contact inhibition and by specific growth factors, such as …