The past two decades have witnessed the emergence of macrocycles, including macrocyclic
peptides, as a promising yet underexploited class of de novo drug candidates. Both …

mRNA display is a powerful biological display platform for the directed evolution of proteins
and peptides. mRNA display libraries covalently link the displayed peptide or protein …

The strong biological rationale to pursue challenging drug targets such as protein–protein
interactions has stimulated the development of novel screening strategies, such as DNA …

In recent decades it has become increasingly clear that induction of autophagy plays an
important role in the development of treatment resistance and dormancy in many cancer …

Highlights•Peptides are a highly versatile class of promising drug candidates.•Peptides can
be both passively and actively cell permeable.•It is now possible to develop cell permeable …

Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–
protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through …

All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …

Therapeutic monoclonal antibodies directed against PD-L1 (eg, atezolizumab) disrupt PD-
L1: PD-1 signaling and reactivate exhausted cytotoxic T-cells in the tumor compartment …

Noncanonical G protein activation and inactivation, particularly for the Gαi/s protein
subfamilies, have long been a focus of chemical research. Combinatorial libraries were …

Accumulation of plastics in the environment became a geological indicator of the
Anthropocene era. An effective reduction of long‐lasting plastics requires a treatment with …