Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

Lentiviral vectors (LVs) are excellent tools to promote gene transfer and stable gene
expression. Their potential has been already demonstrated in gene therapy clinical trials for …

Gammaretroviral and lentiviral vectors (γ‐RV and LV) are among the most used vectors in
gene therapy. Currently, human embryonic kidney (HEK) 293 cells, the manufacture platform …

The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is
associated with poor clinical prognosis. Hence, therapies targeting oncogenic JAG1 hold …

Many mammalian cell lines used in the manufacturing of biopharmaceuticals exhibit high
glycolytic flux predominantly channeled to the production of lactate. The accumulation of …

Cell-based assays are essential for virus functional characterization in fundamental and
applied research. Overcoming the limitations of virus-labelling strategies while allowing …

Lentiviral vectors (LV) are potent tools in delivering genetic information for vac-cines and
therapeutic benefits. Bioprocessing of LV remains challenging, with vec-tor generation …

Gammaretrovirus and lentivirus are the preferred viral vectors to genetically modify T and
natural killer cells to be used in immune cell therapies. The transduction efficiency of …

The Notch signaling ligand JAG1 is overexpressed in various aggressive tumors and is
associated with poor clinical prognosis. Hence, therapies targeting oncogenic JAG1 hold …

The last decades have been marked by a rising number of diseases attributed to newly
discovered viruses, as well as an increasing incidence of diseases caused by viral …