Regulatory T-cell therapy in transplantation: moving to the clinic
Q Tang, JA Bluestone - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …
efficacy is well documented in animal models. Moreover, human Tregs can be identified …
[HTML][HTML] Regulatory T cells as immunotherapy
BD Singer, LS King, FR D'Alessio - Frontiers in immunology, 2014 - frontiersin.org
Regulatory T cells (Tregs) suppress exuberant immune system activation and promote
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …
[HTML][HTML] All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
MJ Benson, K Pino-Lagos, M Rosemblatt… - The Journal of …, 2007 - ncbi.nlm.nih.gov
We demonstrate that all-trans retinoic acid (RA) induces FoxP3+ adaptive T regulatory cells
(A-Tregs) to acquire a gut-homing phenotype (α4β7+ CC chemokine receptor 9+) and the …
(A-Tregs) to acquire a gut-homing phenotype (α4β7+ CC chemokine receptor 9+) and the …
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
JC Ochando, C Homma, Y Yang, A Hidalgo… - Nature …, 2006 - nature.com
The induction of alloantigen-specific unresponsiveness remains an elusive goal in organ
transplantation. Here we identify plasmacytoid dendritic cells (pDCs) as phagocytic antigen …
transplantation. Here we identify plasmacytoid dendritic cells (pDCs) as phagocytic antigen …
Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells
L Wang, K Pino-Lagos, VC de Vries… - Proceedings of the …, 2008 - National Acad Sciences
Although mature dendritic cells (DCs) are potent initiators of adaptive immune response,
immature steady-state DCs contribute to immune tolerance. In this study, we show that ex …
immature steady-state DCs contribute to immune tolerance. In this study, we show that ex …
[HTML][HTML] Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-κB activation
C O'Mahony, P Scully, D O'Mahony, S Murphy… - PLoS …, 2008 - journals.plos.org
Host defence against infection requires a range of innate and adaptive immune responses
that may lead to tissue damage. Such immune-mediated pathologies can be controlled with …
that may lead to tissue damage. Such immune-mediated pathologies can be controlled with …
[HTML][HTML] Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential
S Yan, K Kotschenreuther, S Deng… - Cellular and molecular life …, 2022 - Springer
Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …
CD4+ CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
IM de Kleer, LR Wedderburn, LS Taams… - The journal of …, 2004 - journals.aai.org
This study investigates the role of CD4+ CD25+ regulatory T cells during the clinical course
of juvenile idiopathic arthritis (JIA). Persistent oligoarticular JIA (pers-OA JIA) is a subtype of …
of juvenile idiopathic arthritis (JIA). Persistent oligoarticular JIA (pers-OA JIA) is a subtype of …
Potentiating maternal immune tolerance in pregnancy: a new challenging role for regulatory T cells
J Alijotas-Reig, E Llurba, JM Gris - Placenta, 2014 - Elsevier
The maternal immune system needs to adapt to tolerate the semi-allogeneic conceptus.
Since maternal allo-reactive lymphocytes are not fully depleted, other local/systemic …
Since maternal allo-reactive lymphocytes are not fully depleted, other local/systemic …
Cutting edge: TGF-β signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+ CD25+ T cells
S Huber, C Schramm, HA Lehr, A Mann… - The Journal of …, 2004 - journals.aai.org
Data regarding the role of TGF-β for the in vivo function of regulatory CD4+ CD25+ T cells
(Treg) are controversial. A transgenic mouse model with impaired TGF-β signaling …
(Treg) are controversial. A transgenic mouse model with impaired TGF-β signaling …