Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

Regulatory T cells (Tregs) suppress exuberant immune system activation and promote
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …

We demonstrate that all-trans retinoic acid (RA) induces FoxP3+ adaptive T regulatory cells
(A-Tregs) to acquire a gut-homing phenotype (α4β7+ CC chemokine receptor 9+) and the …

The induction of alloantigen-specific unresponsiveness remains an elusive goal in organ
transplantation. Here we identify plasmacytoid dendritic cells (pDCs) as phagocytic antigen …

Although mature dendritic cells (DCs) are potent initiators of adaptive immune response,
immature steady-state DCs contribute to immune tolerance. In this study, we show that ex …

Host defence against infection requires a range of innate and adaptive immune responses
that may lead to tissue damage. Such immune-mediated pathologies can be controlled with …

Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …

This study investigates the role of CD4+ CD25+ regulatory T cells during the clinical course
of juvenile idiopathic arthritis (JIA). Persistent oligoarticular JIA (pers-OA JIA) is a subtype of …

The maternal immune system needs to adapt to tolerate the semi-allogeneic conceptus.
Since maternal allo-reactive lymphocytes are not fully depleted, other local/systemic …

Data regarding the role of TGF-β for the in vivo function of regulatory CD4+ CD25+ T cells
(Treg) are controversial. A transgenic mouse model with impaired TGF-β signaling …