A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay
Lung cancer (LC) is the most common cancer-related death globally, and many efforts have
been made to improve the patient care of LC patients, as well as the development of efficient …
been made to improve the patient care of LC patients, as well as the development of efficient …
Infection by high-risk human papillomaviruses, epithelial-to-mesenchymal transition and squamous pre-malignant or malignant lesions of the uterine cervix: a series of …
Wound healing requires static epithelial cells to gradually assume a mobile phenotype
through a multi-step process termed epithelial-to-mesenchymal transition (EMT). Although it …
through a multi-step process termed epithelial-to-mesenchymal transition (EMT). Although it …
Langerhans cells shape postnatal oral homeostasis in a mechanical-force-dependent but microbiota and IL17-independent manner
Y Jaber, Y Netanely, R Naamneh, O Saar… - Nature …, 2023 - nature.com
The postnatal interaction between microbiota and the immune system establishes lifelong
homeostasis at mucosal epithelial barriers, however, the barrier-specific physiological …
homeostasis at mucosal epithelial barriers, however, the barrier-specific physiological …
Molecular docking, synthesis and anticancer activity of thiosemicarbazone derivatives against MCF-7 human breast cancer cell line
Background The aim of this study was to synthesize and evaluate anticancer activity of 2-
hydroxy benzaldehyde and 4-hydroxy benzaldehyde thiosemicarbazone (2-HBTSc and 4 …
hydroxy benzaldehyde and 4-hydroxy benzaldehyde thiosemicarbazone (2-HBTSc and 4 …
p53 signaling in cancers
N Issaeva - Cancers, 2019 - mdpi.com
This special issue on p53 explores different aspects of the significance of p53 in normal cells
and in cancer. Currently, everyone working in the area of cell biology knows about the tumor …
and in cancer. Currently, everyone working in the area of cell biology knows about the tumor …
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors
Y Zhu, W Sun, X Jiang, R Bai, Y Luo, Y Gao, S Li… - PloS one, 2023 - journals.plos.org
Background The WD40-encoding RNA antisense to p53 (WRAP53) is an antisense gene of
TP53 with three transcriptional start sites producing three transcript variants involved in the …
TP53 with three transcriptional start sites producing three transcript variants involved in the …
ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation
Y Ning, N Hui, B Qing, Y Zhuo, W Sun, Y Du, S Liu… - Cell death & …, 2019 - nature.com
The activation of p53 tumor suppressor is essential for preventing abnormal cell proliferation
and carcinogenesis. ZCCHC10 was previously identified as a potential p53-interacting …
and carcinogenesis. ZCCHC10 was previously identified as a potential p53-interacting …
P53‑microRNA interactions regulate the response of colorectal tumor cells to oxaliplatin under normoxic and hypoxic conditions
J Zhang, C Li, L Sun, D Sun… - Oncology Reports, 2023 - spandidos-publications.com
Oxaliplatin (OXA)‑containing regimens are used as first‑line chemotherapy in colorectal
cancer (CRC). However, OXA resistance remains a major challenge in CRC treatment. CRC …
cancer (CRC). However, OXA resistance remains a major challenge in CRC treatment. CRC …
Integrated Multiomics Reveals Silencing of has_circ_0006646 Promotes TRIM21‐Mediated NCL Ubiquitination to Inhibit Hepatocellular Carcinoma Metastasis
X Hu, G Chen, Y Huang, Q Cheng, J Zhuo… - Advanced …, 2024 - Wiley Online Library
Recent studies suggest that circular RNA (circRNA)‐mediated post‐translational
modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis of …
modification of RNA‐binding proteins (RBP) plays a pivotal role in metastasis of …
Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human …
Z Ju, J Shao, M Zhou, J Jin, H Pan, P Ding, R Huang - Cell & Bioscience, 2021 - Springer
Background Silica exposure underlies the development of silicosis, one of the most serious
occupational hazards worldwide. We aimed to explore the interaction of the silica-induced …
occupational hazards worldwide. We aimed to explore the interaction of the silica-induced …