Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …
[HTML][HTML] Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …
mammalian brain, essential not only to the development of the central nervous system but …
Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6
Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease resulting in motor
coordination deficits and cerebellar pathology. Expression of brain-derived neurotrophic …
coordination deficits and cerebellar pathology. Expression of brain-derived neurotrophic …
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges
ABSTRACT Introduction Cerebellar ataxias (CAs) represent neurological disorders with
multiple etiologies and a high phenotypic variability. Despite progress in the understanding …
multiple etiologies and a high phenotypic variability. Despite progress in the understanding …
[HTML][HTML] BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1
Abstract Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited
neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 …
neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 …
[HTML][HTML] Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1
C Nanclares, JA Noriega-Prieto… - Neurobiology of …, 2023 - Elsevier
Abstract Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by an
abnormal expansion of glutamine (Q) encoding CAG repeats in the ATAXIN1 (ATXN1) gene …
abnormal expansion of glutamine (Q) encoding CAG repeats in the ATAXIN1 (ATXN1) gene …
[HTML][HTML] Ablation of TrkB from Enkephalinergic Precursor-Derived Cerebellar Granule Cells Generates Ataxia
E Eliseeva, MY Malik, L Minichiello - Biology, 2024 - mdpi.com
Simple Summary Patients suffering from ataxia disorders show symptoms of incoordination
often attributed to cerebellar dysfunction and eventual degeneration of Purkinje cells (PCs) …
often attributed to cerebellar dysfunction and eventual degeneration of Purkinje cells (PCs) …
[HTML][HTML] Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases
S Issa, H Fayoud, A Shaimardanova, A Sufianov… - Biomedicines, 2024 - mdpi.com
Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's,
Huntington's disease, and others are primarily characterized by their progressive nature …
Huntington's disease, and others are primarily characterized by their progressive nature …
Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation‐induced fear memory impairment in mice
T Ma, L Feng, SN Wei, YY Wang, GH Li, Y Lu… - Brain and …, 2023 - Wiley Online Library
Introduction Regulation of brain‐derived neurotrophic factor (BDNF) in the basal forebrain
ameliorates sleep deprivation‐induced fear memory impairments in rodents. Antisense …
ameliorates sleep deprivation‐induced fear memory impairments in rodents. Antisense …
BDNF and Cerebellar Ataxia
R Lalonde, M Hernandez… - Current Drug Research …, 2024 - benthamdirect.com
Brain-derived neurotrophic factor (BDNF) has been proposed as a treatment for
neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its …
neurodegeneration, including diseases of the cerebellum, where BDNF levels or those of its …