Present application and perspectives of organoid imaging technology

K Fei, J Zhang, J Yuan, P Xiao - Bioengineering, 2022 - mdpi.com
An organoid is a miniaturized and simplified in vitro model with a similar structure and
function to a real organ. In recent years, the use of organoids has increased explosively in …

Recent trends and perspectives in cerebral organoids imaging and analysis

C Brémond Martin, C Simon Chane… - Frontiers in …, 2021 - frontiersin.org
Purpose: Since their first generation in 2013, the use of cerebral organoids has spread
exponentially. Today, the amount of generated data is becoming challenging to analyze …

High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos

P Mukashyaka, P Kumar, DJ Mellert, S Nicholas… - Nature …, 2023 - nature.com
Abstract Three-dimensional (3D) organoid cultures are flexible systems to interrogate
cellular growth, morphology, multicellular spatial architecture, and cellular interactions in …

Segmentation and tracking of mammary epithelial organoids in brightfield microscopy

L Hradecká, D Wiesner, J Sumbal… - … on Medical Imaging, 2022 - ieeexplore.ieee.org
We present an automated and deep-learning-based workflow to quantitatively analyze the
spatiotemporal development of mammary epithelial organoids in two-dimensional time …

Mammary organoids and 3D cell cultures: old dogs with new tricks

J Sumbal, Z Budkova, GÁ Traustadóttir… - Journal of Mammary …, 2020 - Springer
Abstract 3D cell culture methods have been an integral part of and an essential tool for
mammary gland and breast cancer research for half a century. In fact, mammary gland …

[HTML][HTML] Cellos: High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology

P Mukashyaka, P Kumar, DJ Mellert, S Nicholas… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Abstract Three-dimensional (3D) culture models, such as organoids, are flexible systems to
interrogate cellular growth and morphology, multicellular spatial architecture, and cell …

[PDF][PDF] 3D Morphological Characterization of Human Cortical Organoids Using a Customized Image Analysis Workflow

S Handcock, KLA Richards, TJ Karle, P Kairath, A Soch… - 2024 - preprints.org
Summary Statement: A tailored image analysis workflow applied to quantify cortical
organoid health, development, morphology and cellular composition over time. Assessment …