Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …

The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

Light-inducible gene switches represent a key strategy for the precise manipulation of
cellular events in fundamental and applied research. However, the performance of widely …

E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many
essential processes, including embryogenesis, wound healing and tissue organization, with …

The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

Light-powered catalysis has found broad utility as a chemical transformation strategy, with
widespread impact on energy, environment, drug discovery and human health. A noteworthy …

The proteolysis targeting chimeras (PROTACs) approach has attracted extensive attention in
the past decade, which represents an emerging therapeutic modality with the potential to …

Embryonic development hinges on effective coordination of molecular events across space
and time. Waves have recently emerged as constituting an ubiquitous mechanism that …

Highlights•Metabolic cybergenetics promises unprecedented real-time control of
fermentations.•Optogenetic regulators make ideal actuators for metabolic cybergenetics.• …

Genes are expressed in stochastic transcriptional bursts linked to alternating active and
inactive promoter states. A major challenge in transcription is understanding how promoter …