A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap

AP Badhwar, GP McFall, S Sapkota, SE Black… - Brain, 2020 - academic.oup.com
Aetiological and clinical heterogeneity is increasingly recognized as a common
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …

Recent progress on branched-chain amino acids in obesity, diabetes, and beyond

MAB Siddik, AC Shin - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in
our body; thus, they need to be obtained from food. They have shown to provide many …

Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites

T Teruya, YJ Chen, Y Fukuji, H Kondoh… - Proceedings of the …, 2021 - pnas.org
Dementia is caused by factors that damage neurons. We quantified small molecular markers
in whole blood of dementia patients, using nontargeted liquid chromatography–mass …

[HTML][HTML] PM2. 5 exposure perturbs lung microbiome and its metabolic profile in mice

J Li, Y Hu, L Liu, Q Wang, J Zeng, C Chen - Science of the Total …, 2020 - Elsevier
Abstract Fine particulate matter (PM2. 5) have become a major public health concern
because of their adverse effects on health. Lungs are considered the primary organ affected …

[HTML][HTML] Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

L Andrisic, D Dudzik, C Barbas, L Milkovic, T Grune… - Redox biology, 2018 - Elsevier
Association of oxidative stress with carcinogenesis is well known, but not understood well,
as is pathophysiology of oxidative stress generated during different types of anti-cancer …

[HTML][HTML] Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy

Y Chen, L Huang, Z Luo, D Han, W Luo, R Wan… - Journal of Controlled …, 2024 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by
metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine …

Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives

S Lista, R González-Domínguez, S López-Ortiz… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …

Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets

P Kodam, R Sai Swaroop, SS Pradhan… - Scientific reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

Amino acid catabolism in Alzheimer's disease brain: friend or foe?

JWD Griffin, PC Bradshaw - Oxidative medicine and cellular …, 2017 - Wiley Online Library
There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …

Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders

B Polis, AO Samson - Neural regeneration research, 2020 - journals.lww.com
Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …