A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap
Aetiological and clinical heterogeneity is increasingly recognized as a common
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …
Recent progress on branched-chain amino acids in obesity, diabetes, and beyond
MAB Siddik, AC Shin - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in
our body; thus, they need to be obtained from food. They have shown to provide many …
our body; thus, they need to be obtained from food. They have shown to provide many …
Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites
T Teruya, YJ Chen, Y Fukuji, H Kondoh… - Proceedings of the …, 2021 - pnas.org
Dementia is caused by factors that damage neurons. We quantified small molecular markers
in whole blood of dementia patients, using nontargeted liquid chromatography–mass …
in whole blood of dementia patients, using nontargeted liquid chromatography–mass …
[HTML][HTML] PM2. 5 exposure perturbs lung microbiome and its metabolic profile in mice
J Li, Y Hu, L Liu, Q Wang, J Zeng, C Chen - Science of the Total …, 2020 - Elsevier
Abstract Fine particulate matter (PM2. 5) have become a major public health concern
because of their adverse effects on health. Lungs are considered the primary organ affected …
because of their adverse effects on health. Lungs are considered the primary organ affected …
[HTML][HTML] Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer
Association of oxidative stress with carcinogenesis is well known, but not understood well,
as is pathophysiology of oxidative stress generated during different types of anti-cancer …
as is pathophysiology of oxidative stress generated during different types of anti-cancer …
[HTML][HTML] Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy
Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by
metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine …
metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine …
Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …
Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets
P Kodam, R Sai Swaroop, SS Pradhan… - Scientific reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …
Amino acid catabolism in Alzheimer's disease brain: friend or foe?
JWD Griffin, PC Bradshaw - Oxidative medicine and cellular …, 2017 - Wiley Online Library
There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …
Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders
Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …
cause of dementia, imposing a growing economic burden upon society. The disease …