Vortioxetine (VTX) is a recently approved antidepressant that targets a variety of serotonin
receptors. Here, we investigate the drug's molecular mechanism of operation at the …

Serotonin receptors (5-HT3AR) play a crucial role in regulating gut movement, and are the
principal target of setrons, a class of high-affinity competitive antagonists, used in the …

The 5-hydroxytrptamine 3 (5-HT3) receptor is a member of the'Cys-loop'family and the only
pentameric ligand gated ion channel among the serotonin receptors. 5-HT3 receptors play …

Agonists enhance receptor activity by providing net-favorable binding energy to active over
resting conformations, with efficiency (η) linking binding energy to gating. Previously, we …

Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels involved in fast
synaptic transmission. Pharmacological inhibition of ASIC1a reduces neurotoxicity and …

The serotonin-gated ion channel (5-HT 3 R) mediates excitatory neuronal communication in
the gut and the brain. It is the target for setrons, a class of competitive antagonists widely …

Combined In-silico and Experimental Approach to Understanding 5-hydroxytryptamine 3 (5-HT3)
Receptor Expression. Page 1 Combined In-silico and Experimental Approach to Understanding …

Dentro de la superfamilia de los canales iónicos activados por ligando (LGIC) se encuentra
la familia de los receptores Cys-loop que incluye a canales catiónicos, como los receptores …