Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

The microorganisms that have developed resistance to available therapeutic agents are
threatening the globe and multidrug resistance among the bacterial pathogens is becoming …

Diabetic wounds (DW) are constantly challenged by excessive reactive oxygen species
(ROS) accumulation and susceptibility to bacterial contamination. Therefore, the elimination …

The emergence of multidrug-resistant Gram-negative bacteria underscores the need to
define genetic vulnerabilities that can be therapeutically exploited. The Gram-negative …

A multi-component cascade cyclization reaction of readily available 2, 4-pentanediones,
primary amines and sodium sulfinates is reported. Highly functionalized 5-alkylidene-3 …

An impermeable outer membrane and multidrug efflux pumps work in concert to provide
Gram-negative bacteria with intrinsic resistance against many antibiotics. These resistance …

Herein, we developed a synthetic strategy for the direct construction of C–S bonds to obtain
biologically active sulfur-containing compounds and a methodology involving the reductive …

The natural product holomycin contains a unique cyclic ene–disulfide and exhibits broad-
spectrum antimicrobial activities. Reduced holomycin chelates metal ions with a high affinity …

Aminoacyl-tRNA synthetases (aaRS) are key enzymes in protein biosynthesis that employ
various editing mechanisms to ensure faithful translation of genetic information. Seryl-tRNA …

A metal-free regioselective oxidative annulation reaction of readily available 2, 4-
pentanediones with primary amines has been described. This protocol provides a divergent …