The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …

The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …

Vaccines and drugs have helped reduce disease severity and blunt the spread of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus …

In vitro transcription (IVT) is a DNA-templated process for synthesizing long RNA transcripts,
including messenger RNA (mRNA). For many research and commercial applications, IVT of …

Maintaining a healthy proteome is fundamental for the survival of all organisms. Integral to
this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding …

Computational methods for protein structure modelling are routinely used to complement
experimental structure determination, thus they help to address a broad spectrum of …

Hsp90 is a conserved and essential molecular chaperone responsible for the folding and
activation of hundreds of 'client'proteins,–. The glucocorticoid receptor (GR) is a model client …

INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …

INTRODUCTION Perceptual experiences in mammals may arise from patterns of neural
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …

Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …