The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Breast cancer is the second leading cancer among all types of cancers. It accounts for 12%
of the total cases of cancers. The complex and heterogeneous nature of breast cancer …

BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …

In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …

Cellular protection against oxidative and electrophile toxicities is provided by two types of
small‐molecule antioxidants:(i) direct antioxidants, which are redox active, short‐lived, are …

Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

The influence of 20nm ZnO nanoparticles on cytotoxicity, oxidative stress, intracellular
calcium homeostasis, and gene expression was studied in human bronchial epithelial cells …

Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …

Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the expression
of a large pool of antioxidant and cytoprotective genes regulating the cellular response to …