Thioredoxin reductase inhibition for cancer therapy
R Gencheva, ESJ Arnér - Annual Review of Pharmacology and …, 2022 - annualreviews.org
The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …
From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
Role of Nrf2 signaling cascade in breast cancer: strategies and treatment
H Kumar, RM Kumar, D Bhattacharjee… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the second leading cancer among all types of cancers. It accounts for 12%
of the total cases of cancers. The complex and heterogeneous nature of breast cancer …
of the total cases of cancers. The complex and heterogeneous nature of breast cancer …
Focus on mammalian thioredoxin reductases—important selenoproteins with versatile functions
ESJ Arnér - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
Dual roles of Nrf2 in cancer
A Lau, NF Villeneuve, Z Sun, PK Wong… - Pharmacological …, 2008 - Elsevier
In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …
Direct and indirect antioxidant properties of inducers of cytoprotective proteins
AT Dinkova‐Kostova, P Talalay - Molecular nutrition & food …, 2008 - Wiley Online Library
Cellular protection against oxidative and electrophile toxicities is provided by two types of
small‐molecule antioxidants:(i) direct antioxidants, which are redox active, short‐lived, are …
small‐molecule antioxidants:(i) direct antioxidants, which are redox active, short‐lived, are …
TrxR1 as a potent regulator of the Nrf2-Keap1 response system
M Cebula, EE Schmidt, ESJ Arnér - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …
Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles
The influence of 20nm ZnO nanoparticles on cytotoxicity, oxidative stress, intracellular
calcium homeostasis, and gene expression was studied in human bronchial epithelial cells …
calcium homeostasis, and gene expression was studied in human bronchial epithelial cells …
Glutathione peroxidases in different stages of carcinogenesis
R Brigelius-Flohe, A Kipp - Biochimica et Biophysica Acta (BBA)-General …, 2009 - Elsevier
Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …
Oncogenic functions of the transcription factor Nrf2
I Gañán-Gómez, Y Wei, H Yang… - Free Radical Biology …, 2013 - Elsevier
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that controls the expression
of a large pool of antioxidant and cytoprotective genes regulating the cellular response to …
of a large pool of antioxidant and cytoprotective genes regulating the cellular response to …