TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Targeted protein degradation (TPD) has emerged as a promising therapeutic approach with
potential advantages over traditional occupancy-based inhibitors in terms of dosing, side …

Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be
involved in antiviral responses and autoimmune diseases. Recently studies have reported …

Protein acetylation modifications play a central and pivotal role in a myriad of biological
processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and …

ABSTRACT HDAC6, a structurally and functionally unique member of the histone
deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad …

Hematopoietic stem and progenitor cells (HSPCs) are cells mainly present in the bone
marrow and capable of forming mature blood cells. However, the epigenetic mechanisms …

The tripartite motif protein 21 (TRIM21) belongs to the TRIM family, possessing an E3
ubiquitin ligase activity. Similar to other TRIMs, TRIM21 also contains three domains (named …

Abstract Proteolysis Targeting Chimeras (PROTACs) represent a significant advancement in
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …

Macrophage polarization determines the production of pro‐or anti‐inflammatory cytokines in
response to various bacterial and virus infections. Here, we report that pro‐inflammatory …

Multiple factors contribute to the development of connective tissue diseases (CTD), often
alongside a range of interstitial lung diseases (ILD), including Sjögren's syndrome …