Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of
mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and …

Cell types rich in mitochondria, including neurons, display a high energy demand and a
need for calcium buffering. The importance of mitochondria for proper neuronal function is …

Loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) or parkin genes, which
encode a mitochondrially localized serine/threonine kinase and a ubiquitin-protein ligase …

Mitochondria are integral elements of many nerve terminals. They must be appropriately
positioned to regulate microdomains of Ca2+ concentration and metabolic demand, but …

Defects in organelle dynamics underlie a number of human degenerative disorders, and
whole exome sequencing (WES) is a powerful tool for studying genetic changes that affect …

How cues that trigger the wound response result in tissue healing is a question of immense
biological and medical importance. Here we uncover roles for mitochondrial reactive oxygen …

The role of mitochondria in Drosophila programmed cell death remains unclear, although
certain gene products that regulate cell death seem to be evolutionarily conserved. We find …

Sarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal
muscle mass and function. Originally defined as an age‐associated condition, sarcopenia …

There are many differences in external morphology and internal physiology between the
Apis mellifera queen bee and worker bee, some of which are relevant to beekeeping …

Mitochondria are highly dynamic organelles with strict quality control processes that
maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated …