HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

C Eggers, G Arendt, K Hahn, IW Husstedt… - Journal of …, 2017 - Springer
The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

The three human monocyte subsets: implications for health and disease

KL Wong, WH Yeap, JJY Tai, SM Ong, TM Dang… - Immunologic …, 2012 - Springer
Human blood monocytes are heterogeneous and conventionally subdivided into two
subsets based on CD16 expression. Recently, the official nomenclature subdivides …

The role of macrophages in HIV-1 persistence and pathogenesis

Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …

Central nervous system viral invasion and inflammation during acute HIV infection

V Valcour, T Chalermchai, N Sailasuta… - The Journal of …, 2012 - academic.oup.com
Background. Understanding the earliest central nervous system (CNS) events during human
immunodeficiency virus (HIV) infection is crucial to knowledge of neuropathogenesis, but …

Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients

P Ancuta, A Kamat, KJ Kunstman, EY Kim, P Autissier… - PloS one, 2008 - journals.plos.org
Elevated plasma lipopolysaccharide (LPS), an indicator of microbial translocation from the
gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces …

Neurological complications of HIV infection

JC McArthur, BJ Brew, A Nath - The Lancet Neurology, 2005 - thelancet.com
Cognitive disorders, vacuolar myelopathy, and sensory neuropathies associated with HIV
are the most common disorders in patients with HIV AIDS, and are the focus of this review …

The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo

PJ Ellery, E Tippett, YL Chiu, G Paukovics… - The Journal of …, 2007 - journals.aai.org
HIV-1 persists in peripheral blood monocytes in individuals receiving highly active
antiretroviral therapy (HAART) with viral suppression, despite these cells being poorly …

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

SH Ramirez, AM Andrews, D Paul… - Fluids and Barriers of the …, 2018 - Springer
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the
blood and other body fluids, which disperse a variety of bioactive molecules (eg, protein …

[HTML][HTML] Neurologic complications of HIV disease and their treatment

SL Letendre, RJ Ellis, BM Ances… - Topics in HIV medicine …, 2010 - ncbi.nlm.nih.gov
Findings on the nervous system complications of HIV disease and their impact on people
living with HIV continue to accumulate. New reports at the 17 th Conference on Retroviruses …

Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy

E Cassol, S Malfeld, P Mahasha… - The Journal of …, 2010 - academic.oup.com
Background. Microbial translocation contributes to immune activation and disease
progression during chronic human immunodeficiency virus type 1 (HIV-1) infection …