The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to
be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has …

The SWI/SNF chromatin remodeling complex uses the energy of ATP hydrolysis to alter
contacts between DNA and nucleosomes, allowing regions of the genome to become …

Genetic mutations and epigenetic modifications affecting multiple cancer-related genes
occur synergistically to drive tumorigenesis. Across a wide spectrum of cancers, pathogenic …

Summary The mammalian SWI/SNF (mSWI/SNF or BAF) family of chromatin remodeling
complexes play critical roles in regulating DNA accessibility and gene expression. The three …

Abstract Background Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is
an increasingly popular technique to map genome-wide binding profiles of histone …

Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma
without a known dysplastic precursor. In some cases, MCC is associated with SCCIS in the …

Abstract SMARCA4 (BRG1) and SMARCA2 (BRM) are the two paralogous ATPases of the
SWI/SNF chromatin remodeling complexes frequently inactivated in cancers. Cells deficient …

Extracranial rhabdoid tumours (ECRTs) are an aggressive malignancy of infancy and early
childhood. The vast majority of cases demonstrate inactivation of SMARCB1 …

The SNF5 subunit of the SWI/SNF chromatin remodeling complex has been shown to act as
a tumor suppressor through multiple mechanisms, including impairing the ability of the …

Simple Summary The rare ovarian cancer subtypes ovarian clear cell carcinoma (OCCC)
and Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT), can have mutations …