Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of
acute myocardial infarction (AMI). However reperfusion is responsible for additional …

Resveratrol is a natural polyphenol found in grapes and wine and has been associated with
protective effects against cardiovascular diseases. In vitro, both resveratrol preconditioning …

An ever-increasing number of studies highlight the role of uncoupling protein 2 (UCP2) in a
broad range of physiological and pathological processes. The knowledge of the molecular …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and
must be applied as soon as possible to attenuate the ischemic insult. However, reperfusion …

Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can
prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells …

The emergence of mitochondria as critical regulators of cardiac myocyte survival and death
has revolutionized the field of cardiac biology. Indeed, it is now well recognized that …