The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

High-conductance voltage-and Ca2+-activated K+ (BK) channels encode negative feedback
regulation of membrane voltage and Ca2+ signaling, playing a central role in numerous …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

BK large conductance voltage-and calcium-activated potassium channels respond to
elevations in intracellular calcium and membrane potential depolarization, braking …

The large conductance calcium-and voltage-activated K+ channel (KCa1. 1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …

Smooth muscle (SM) is essential to all aspects of human physiology and, therefore, key to
the maintenance of life. Ion channels expressed within SM cells regulate the membrane …

Large conductance, Ca 2+-activated potassium (BK) channels are widely expressed
throughout the animal kingdom and play important roles in many physiological processes …