Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Extracellular vesicle analysis

A Hendrix, L Lippens, C Pinheiro, C Théry… - Nature Reviews …, 2023 - nature.com
Cells release small, phospholipid membrane-enclosed particles, collectively referred to as
extracellular vesicles (EVs), into their surroundings to enable intercellular communication …

A brief history of nearly EV‐erything–The rise and rise of extracellular vesicles

Y Couch, EI Buzàs, D Di Vizio, YS Gho… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the
extracellular space. The field of EVs has grown exponentially over the past two decades; this …

Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer

JR Melamed, SS Yerneni, ML Arral, ST LoPresti… - Science …, 2023 - science.org
Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …

Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Comprehensive isolation of extracellular vesicles and nanoparticles

Q Zhang, DK Jeppesen, JN Higginbotham… - Nature protocols, 2023 - nature.com
There is an increasing appreciation for the heterogeneous nature of extracellular vesicles
(EVs). In addition, two nonvesicular extracellular nanoparticles (NVEPs), exomeres and …

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

M Mathieu, N Névo, M Jouve, JI Valenzuela… - Nature …, 2021 - nature.com
Despite their roles in intercellular communications, the different populations of extracellular
vesicles (EVs) and their secretion mechanisms are not fully characterized: how and to what …