The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

The tooth root is an integral, functionally important part of our dentition. The formation of a
functional root depends on epithelial-mesenchymal interactions and integration of the root …

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for
regenerative medicine for a wide range of applications. Here we report a new population of …

Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for
the study of epithelial organ development and evolution. Here, we review the developmental …

Most characteristics of tooth shape and pattern can be altered by modulating the signal
pathways mediating epithelial–mesenchymal interactions in developing teeth. These …

Organ development requires complex signaling by cells in different tissues. Epithelium and
mesenchyme interactions are crucial for the development of skin, hair follicles, kidney, lungs …

Vertebrate dentitions originated in the posterior pharynx of jawless fishes more than half a
billion years ago. As gnathostomes (jawed vertebrates) evolved, teeth developed on oral …

Background information. Although adult bone‐marrow‐derived cell populations have been
used to make teeth when recombined with embryonic oral epithelium, the differences …

Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate
and invertebrate models revealed the TGF-β family to be central regulators of tissue …

Integuments form the boundary between an organism and the environment. The evolution of
novel developmental mechanisms in integuments and appendages allows animals to live in …