Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Epithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant
behaviors of cancers, including proliferation, invasion, and metastasis. Most notably, previou …

Recent studies have established a strong link between copper and cancer biology, as
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …

Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth
most deadly cancer worldwide. CRC accounts for approximately 10% of all new cancer …

Abstract Rationale: Cancer stem cells (CSCs) are considered to be essential for
tumorigenesis, recurrence, and metastasis and therefore serve as a biomarker for tumor …

Background Colon cancer (CC) cells can exhibit stemness and expansion capabilities,
which contribute to resistance to conventional chemotherapies. Aberrant expression of …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Radiotherapeutic resistance is a major obstacle for the effective treatment of colorectal
cancer (CRC). MicroRNAs (miRNAs) play a critical role in chemoresistance and …

Background Stemness refers to the capacities of self-renewal and repopulation, which
contributes to the progression, relapse, and drug resistance of colorectal cancer (CRC) …