A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Long-lived structural proteins, collagen and elastin, undergo continual non-enzymatic
crosslinking during aging and in diabetic individuals. This abnormal protein crosslinking is …

Cerebral ischemia induces a rapid and dramatic up-regulation of tumor necrosis factor (TNF)
protein and mRNA, but the cellular sources of TNF in the ischemic brain have not been …

Mild hypothermia is neuroprotective, but the reasons are not well known. Inflammation
contributes to ischemic damage; therefore, we examined whether the protection by …

Spinal cord injury (SCI) results in immediate damage followed by a secondary phase of
tissue damage that occurs over a period of several weeks. The mechanisms underlying this …

Ischemic brain injury is a major problem associated with stroke. It has been increasingly
recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic …

Background and Purpose—The neurotoxic and neuroprotective role of nitric oxide (NO) in
experimental cerebral ischemia has generated considerable debate. The aim of this study …

Nitric oxide (NO) derived from the inducible isoform of NO synthase (iNOS) is an
inflammatory product implicated both in secondary damage and in recovery from brain …

The effort to develop effective therapies for acute ischemic stroke achieved several im-
portant successes during the past decade, but also many disappointing failures. The 2 …