The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …

Developmental enhancers initiate transcription and are fundamental to our understanding of
developmental networks, evolution and disease. Despite their importance, the properties …

Chromatin loops between gene pairs have been observed in diverse contexts in both flies
and vertebrates. Combining high-resolution Capture-C, DNA fluorescence in situ …

Dorsal closure and head involution are complex morphogenetic processes that occur nearly
simultaneously, midway through Drosophila embryonic development. While dorsal closure …

The BMP signaling pathway has a conserved role in dorsal-ventral axis patterning during
embryonic development. In Drosophila, graded BMP signaling is transduced by the Mad …

The generation, differentiation, and migration of newborn neurons are critical features of
normal brain development that are subject to both extracellular and intracellular regulation …

Single-cell chromatin studies provide insights into how chromatin structure relates to
functions of individual cells. However, balancing high-resolution and genome wide …

Previously our results showed miR-222-3p was significantly downregulated in retinoic acid-
induced neural tube defect (NTD) mouse model through transcriptome. Down-regulation of …

The mTORC1 kinase promotes cell growth in response to growth factors by activation of
receptor tyrosine kinase. It is regulated by the cellular energy level and the availability of …

Abstract Background For their transmission, African trypanosomes rely on their blood
feeding insect vector, the tsetse fly (Glossina sp.). The ingested Trypanosoma brucei …