Despite a growing neuroimaging literature on the pathophysiology of major depressive
disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample …

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing
body of evidence has suggested its crucial role in the pathophysiology of major depressive …

Thalamocortical circuitry has a substantial impact on emotion and cognition. Previous
studies have demonstrated alterations in thalamocortical functional connectivity (FC) …

Background Late-life depression (LLD) is a common and serious mental disorder, whose
neural mechanisms are not yet fully understood. In this study, we aimed to characterize LLD …

Functional homotopy, the high degree of spontaneous activity synchrony and functional
coactivation between geometrically corresponding interhemispheric regions, is a …

BackgroundThe age-related heterogeneity in major depressive disorder (MDD) has
received significant attention. However, the neural mechanisms underlying such …

Background Evidence has established the prominent involvement of rapid eye movement
(REM) sleep disturbance in major depressive disorder (MDD). However, the neural …

Major depressive disorder (MDD) is a common psychiatric disorder which is associated with
an accelerated biological aging. However, little is known whether such process would be …

Background The advances in resting-state functional magnetic resonance imaging
techniques motivate parsing heterogeneity in major depressive disorder (MDD) through …

Major depressive disorder (MDD) typically manifests itself in depressed affect, anhedonia,
low energy, and additional symptoms. Despite its high global prevalence, its …