Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase
cascades in their repertoire of signal transduction mechanisms. Recent advances in the …

Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of
osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of …

Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

Background and aims: Growth factors are well known for their participation in the regulation
of cell proliferation and survival. However, the intracellular signaling pathways by which …

Activated Ras proteins have either positive or negative effects on the regulation of apoptosis
depending on cell type and other factors. In part, this is due to the ability of Ras to control …

Apoptosis is a form of programmed cell death that plays a pivotal role during development
and in the homeostasis of the adult nervous systems. However, mechanisms that regulate …

Extracellular growth factors are required for the survival of most animal cells. They often
signal through the activation of the Ras pathway. However, the molecular mechanisms by …